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In a clinical trial where neither the participants nor the researchers knew who received the actual drug or a fake pill (placebo), 314492 adults who were overweight or obese (with an average body mass index of 36.2) were randomly assigned to take either lorcaserin (10 mg) or placebo twice a day for 52 weeks

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[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Kim M, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, Seino S, Simpson JA, Drucker DJ

To support tolerance, GLP-1 treatment is started at a low dose and titrated upward, which helps reduce gastrointestinal side effects like nausea that can affect 20% to 40% of patients when treatment begins , as noted in the earlier payer-focused clinical guidance